<2022>

 

Imaizumi S, Yoshida S, Kanegae Y, and Yoshida K. Enforced dual-specificity tyrosine-regulated kinase 2 expression by adenovirus-mediated gene transfer inhibits tumor growth and metastasis of colorectal cancer. Cancer Sci. 113:960-970 (2022)

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　Highlighted in ‘In This Issue’ of Cancer Sci. 113:813-814 (2022)

 

Yamada K and Yoshida K. Multiple subcellular localizations and functions of protein kinase Cdelta in liver cancer. World J. Gastroenterol. 28:188 (2022)

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Yamada K, Kizawa R, Yoshida A, Koizumi R, Motohashi S, Shimoyama Y, Hannya Y, Yoshida S, and Yoshida K. Extracellular PKCdelta signals to epidermal growth factor receptor fot tumor proliferation in liver cancer cells. Cancer Sci. 113:2378-2385 (2022)

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Kawamura A, Yoshida S, Aoki K, Shimoyama Y, Yamada K, and Yoshida K. DYRK2 maintains genome stability via neddylation of cullins in response to DNA damage. J. Cell Sci. 135:jcs259514 (2022)

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• プレスリリースはこちら

• First person - Akira Kawamura J. Cell Sci. 135:jcs260276 (2022)

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Yamada K, Motohashi S, Oikawa T, Tago N, Koizumi R, Ono M, Tachibana T, Yoshida A, Yoshida S, Shimoda M, Oka M, Yoneda Y, and Yoshida K. Extended-synaptotagmin 1 engages in unconventional prtein secretion mediated via SEC22B+ vesicle pathway in liver cancer. PNAS 119:e2202730119 (2022)

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• プレスリリースはこちら

• 時事メディカル　「肝がんにおけるタンパク質の新しい分泌機構の解明〜肝がんの早期発見や新規治療法への応用に期待〜」 

• 日経バイオテク　「慈恵医大、肝がん超早期マーカーPKCδの有用性を確認」

 

<2021>

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Yogosawa S, Ohkido M, Horii T, Okazaki Y, Nakayama J, Yoshida S, Toyokuni S, Hatada I, Morimoto M, and Yoshida K. Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient. Commun. Biol. 4:1204 (2021)

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　プレスリリースはこちら

　 QLife Pro、医療ニュース「VATER症候群に近い病態を示すモデルマウスの作製に成功ー慈恵大ほか」

 

Niino YS, Kawashima I, Iguchi Y, Kanda H, Ogura K, Mita-Yoshida K, Ono T, Yamazaki M, Sakimura K, Yogosawa S, Yoshida K, Shioda S, Gotoh T. PKCdelta deficiency inhibits fetal development and is associated with heart elastic fiber hyperplasia and lung inflammation in adult PKCdelta knockout mice. PLoS One 16:e0253912 (2021)

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Klionsky, DJ, …Yoshida K, …Tong CK. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 17:1-382 (2021)

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Yogosawa S, Nakayama J, Nishi M, Ryo A, and Yoshida K. Carbonic anhydrase 13 suppresses bone metastasis in breast cancer. Cancer Treat. Res. Commun. 27:100332 (2021)

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Yamada K, Oikawa T, Kizawa R, Motohashi S, Yoshida S, Kumamoto T, Saeki C, Nakagawa C, Shimoyama Y, Aoki K, Tachibana T, Saruta M, Ono M, and Yoshida K. Unconventional secretion of PKCdelta exerts tumorigenic function via stimulation of ERK1/2 signaling in liver cancer. Cancer Res. 81:414-425 (2021)

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　プレスリリースはこちら

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<2020>

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Yoshida S, Aoki K, Fujiwara K, Nakakura T, Kawamura A, Yamada K, Ono M, Yogosawa S, and Yoshida K. The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis. eLife 9:e57381 (2020)

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　プレスリリースはこちら

　BPoD "A Helping Hair"

 

Kumamoto T, Yamada K, Yoshida S, Aoki K, Hirooka S, Eto K, Yanaga K, and Yoshida K. Impairment of DYRK2 by DNMT-mediated transcription augments carcinogenesis in human colorectal cancer.​​  Int. J. Oncol. 56:1529-1539 (2020) 

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<2019>

 

Yoshida S and Yoshida K. Multiple functions of DYRK2 in cancer and tissue development. FEBS Lett. 593:2953-2965 (2019)

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Mimoto R, Yogosawa S, Saijo H, Fushimi A, Nogi H, Asakura T, Yoshida K, and Takeyama H. Clinical implications of drug-screening assay for recurrent metastatic hormone receptor-positive, human epidermal receptor 2-negative breast cancer using conditionally reprogrammed cells. Sci. Rep. 9:13405 (2019) 

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Yokoyama-Mashima S, Yogosawa S, Kanegae Y, Hirooka S, Yoshida S, Horiuchi T, Ohashi T, Yanaga K, Saruta M, Oikawa T, and Yoshida K. Forced expression of DYRK2 exerts anti-tumor effects via apoptotic induction in liver cancer. Cancer Lett. 451:100-109 (2019)

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Yamada K and Yoshida K. Mechanical insights into the regulation of programmed cell death by p53 via mitochondria. BBA - Mol. Cell Res. 1866:839-848 (2019)

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Nomoto H, Maehashi H, Shirai M, Nakamura M, Masaki T, Mezaki Y, Park J, Aizawa M, Ohkawa K, Yoshida K, and Matsuura T. Bio-artificial bone formation model with a radial-flow bioreactor for implant therapy-comparison between two cell culture carriers: porous hydroxyapatite and β-tricalcium phosphate beads. Hum. Cell 32:1-11 (2019)

​

<2018>

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Okabe H, Aoki K, Yogosawa S, Saito M, Marumo K, and Yoshida K. Downregulation of CD24 suppresses bone metastasis of lung cancer. Cancer Sci. 109:112-120 (2018)

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Imawari Y, Mimoto R, Hirooka S, Morikawa T, Takeyama H, and Yoshida K. Downregulation of dual-specificity tyrosine-regulated kinase 2 promotes tumor cell proliferation and invasion by enhancing CDK14 expression in breast cancer. Cancer Sci. 109:363 -372 (2018)

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Yogosawa S and Yoshida K. Tumor suppressive role for kinases phosphorylating p53 in the DNA damage-induced apoptosis. Cancer Sci. 109:3376 -3382 (2018)

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<2017>

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Mimoto R, Imawari Y, Hirooka S, Takeyama H, and Yoshida K. Impairment of DYRK2 augments stem-like traits by promoting KLF4 expression in breast cancer. Oncogene 36:1862-1872 (2017)

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Mimoto R, Nihira NT, Hirooka S, Takeyama H, and Yoshida K. Diminished DYRK2 sensitizes hormone receptor-positive breast cancer to everolimus by the escape from degrading mTOR. Cancer Lett. 384:27-38 (2017)

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Yamamoto T, Nihira NT, Yogosawa S, Aoki K, Takeda H, Sawasaki T, and Yoshida K. Interaction between RNF8 and DYRK2 is required for the recruitment of DNA repair molecules to DNA double-strand breaks. FEBS Lett. 591:842 -853 (2017)

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Honda M, Yogosawa S, Kamada M, Kamata Y, Kimura T, Koike Y, Harada T, Takahashi H, Egawa S, and Yoshida K. A novel near-infrared fluorescent protein, iRFP720, facilitates transcriptional profiling of prostate cancer bone metastasis in mice. Anticancer Res. 37:3009-3013 (2017)

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Ito D, Yogosawa S, Mimoto R, Hirooka S, Horiuchi T, Eto K, Yanaga K, and Yoshida K. Dual-specificity tyrosine-regulated kinase 2 is a suppressor and potential prognostic marker for liver metastasis of colorectal cancer. Cancer Sci. 108:1565-1573 (2017)

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Kagami Y, Ono M, and Yoshida K. Plk1 phosphorylation of CAP-H2 triggers chromosome condensation by condensin II at the early phase of mitosis. Sci. Rep. 7:5583 (2017)

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Aoki K and Yoshida K. Biological consequences of priming phosphorylation in cancer development. In: Claude Prignet (ed). Protein Phosphorylation. InTech. pp.73-96 (2017)

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三本麗、吉田清嗣　『癌幹細胞の概念』　「日本臨床」75増刊号3 (乳癌学—最新の診断と治療—): 102-106 (2017)

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<2016>

 

Dashzeveg N and Yoshida K. Crosstalk between tumor suppressors p53 and PKCdelta: Execution of the intrinsic apoptotic pathways. Cancer Lett. 377:158-163 (2016)

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Dashzeveg N, Yogosawa S, and Yoshida K. Transcriptional induction of protein kinase C delta by p53 tumor suppressor in the apoptotic response to DNA damage. Cancer Lett. 374:167-174 (2016)

 

Kagami Y and Yoshida K. The functional role for condensin in the regulation of chromosomal organization during the cell cycle. Cell. Mol. Life Sci. 73:4591-4598 (2016)

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<2015>

 

Matsumoto M, Matsuura T, Aoki K, Maehashi H, Iwamoto T, Ohkawa K, Yoshida K, Yanaga K, and Takada K. An efficient system for secretory production of fibrinogen using a hepatocellular carcinoma cell line. Hepatol. Res. 45:315-325 (2015)

 

Asakura T, Yamaguchi N, Ohkawa K, and Yoshida K. Proteasome inhibitor-resistant cells cause EMT-induction via suppression of E-cadherin by miR-200 and ZEB1. Int. J. Oncol. 46:2251-2260 (2015)

 

Yamaguchi N, Mimoto R, Yanaihara N, Imawari Y, Hirooka S, Okamoto A, and Yoshida K. DYRK2 regulates epitherial-mesenchymal-transition and chemosensitivity through Snail degradation in ovarian serous adenocaricinoma. Tumor Biol. 36:5913-5823 (2015)

 

Nihira NT and Yoshida K. Engagement of DYRK2 in proper control for cell division. Cell Cycle 14:802-807 (2015)

 

Dashzeveg N and Yoshida K. Cell death decision by p53 via control of the mitochondrial membrane. Cancer Lett. 367:108-112 (2015)

 

<2014>

 

Taira N, Yamaguchi T, Kimura J, Lu Z-G, Fukuda S, Higashiyama S, Ono M, and Yoshida K. Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage. Proc. Natl. Aca. Sci. USA 111: 717-722 (2014)

 

　プレスリリースはこちら

　新聞報道（産経新聞、時事通信、日刊工業新聞、科学新聞）

 

Kagami Y, Nihira K, Wada S, Ono M, Honda M, and Yoshida K. Mps1 phosphorylation of condensin II controls chromosome condensation at the onset of mitosis. J. Cell Biol. 205:781-790 (2014)

 

　プレスリリースはこちら

　Highlighted in ‘In This Issue’ of J. Cell Biol. 205:754 (2014)

 

Dashzeveg N, Taira N, Lu Z-G, Kimura J, and Yoshida K. Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage. Cell Death & Dis. 5:e1221 (2014)

 

Nakazawa K, Dashzeveg N, and Yoshida K. Tumor supressor p53 induces miR-1915 processing to inhibit Bcl-2 in the apoptotic response to DNA damage. FEBS J. 281:2937-2944 (2014)

 

<2013>

 

Mimoto R, Taira N, Takahashi H, Yamaguchi T, Okabe M, Uchida K, Miki Y, and Yoshida K. DYRK2 controls epithelial-mesenchymal transition in breast cancer by degrading Snail. Cancer Lett. 339:214-225 (2013)

 

<2012>

 

Suzuki K, Dashzeveg N, Lu Z-G, Taira N, Miki Y, and Yoshida K. PDCD6, a novel p53-responsive gene, targets to the nucleus in the apoptotic response to DNA damage. Cancer Sci. 103: 1788-1794 (2012)

 

Taira N, Mimoto R, Kurata M, Yamaguchi T, Kitagawa M, Miki Y, and Yoshida K. DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. J. Clin. Invest. 122:859–872 (2012)

 

　プレスリリースはこちら、Press Release in English、米国Public release

　新聞報道（時事通信、日経産業新聞、化学工業日報、科学新聞、Japan Medicine Monthly）　

 

Taira N and Yoshida K. Post-translational modifications of p53 tumor suppressor: determinants of its functional targets. Histol. Histopathol. 27:437-443 (2012)

 

平直江、吉田清嗣　『抗腫瘍性キナーゼによる細胞周期制御とがんの進展』「実験医学」30:1786-1789 (2012)

 

吉田清嗣　『PKCシグナル』「キーワードで理解するシグナル伝達イラストマップ」改訂版 74-76 (2012)　羊土社

 

<2011>

 

Hew HC, Liu H, Lu-Z-G, Kimura J, Miki Y, and Yoshida K. Identification of Evi-1 as a novel effector of PKCdelta in the apoptotic response to DNA damage. Biochim. Biophys. Acta 1809:285-294 (2011)

 

Hew HC, Liu H, Miki Y, and Yoshida K. PKCdelta regulates Mdm2 independently of p53 in the apoptotic response to DNA damage. Mol. Carcinog. 50:719-731 (2011)

 

Kimura J, Kudoh T, Miki Y, and Yoshida K. Identification of dihydropyrimidinase-related protein 4 as a novel target of the p53 tumor suppressor in the apoptotic response to DNA damage. Int. J. Cancer 128:1524-1531 (2011)

 

Yoshida K. Role for PKCdelta on apoptosis in the DNA damage response. In: Chen CC (ed), Selected Topics in DNA Repair. InTech. pp.293-304 (2011)

 

吉田清嗣　『アポトーシス誘導におけるPKC』「Surgery Frontier」18:62-65 (2011)

 

<2010>

 

Kudoh T, Kimura J, Lu Z-G, Miki Y, and Yoshida K. D4S234E, a novel p53-responsive gene, induces apoptosis in response to DNA damage. Exp. Cell Res. 316:2849-2858 (2010)

 

Yamaguchi T, Miki Y, and Yoshida K. The c-Abl tyrosine kinase stabilizes Pitx1 in the apoptotic response to DNA damage. Apoptosis 15:927-935 (2010)

 

Taira N, Yamamoto H, Yamaguchi T, Miki Y, and Yoshida K. ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage. J. Biol. Chem. 285:4909-4919 (2010)

 

Nihira K, Ando Y, Yamaguchi T, Kagami Y, Miki Y, and Yoshida K. Pim1 controls NF-kappaB signalling by stabilizing RelA/p65. Cell Death Differ. 17:689-698 (2010)

 

Yoshida K, Miki Y. The cell death machinery governed by the p53 tumor suppressor in response to DNA damage. Cancer Sci. 101:831-835 (2010)

 

Yoshida K. PKC, p53, and DNA damage. In: Kazanietz MG (ed), Protein Kinase C in Cancer Signaling and Therapy. Springer Science & Business Media. pp.253-265 (2010)

 

吉田清嗣　『DNA傷害によるキナーゼ活性化機構とアポトーシス誘導制御』「実験医学」28増刊号 (細胞死研究総集編): 1023-1028 (2010)

 

<2009>

 

Liu H, Hew HC, Lu Z-G, Yamaguchi T, Miki Y, and Yoshida K. DNA damage signalling recruits RREB-1 to the p53 tumor suppressor promoter. Biochem. J. 422:543-551 (2009)

 

Lu Z-G, Liu H, Yamaguchi T, Miki Y, and Yoshida K. Protein kinase Cdelta activates RelA/p65 and nuclear factor-kappaB signaling in response to tumor necrosis factor-alpha. Cancer Res. 69:5927-5935 (2009)

 

Yoshida K. Cell signaling, cell cycle defect and apoptosis in Cockayne syndrome. In: Ahmead SI (ed), Molecular Mechanisms of Cockayne Syndrome. Landes Bioscience, Inc. pp.43-51 (2009)

 

<2008>

 

Nihira K, Taira N, Miki Y, and Yoshida K. TTK/Mps1 controls nuclear targeting of c-Abl by 14-3-3-coupled phosphorylation in response to oxidative stress. Oncogene 27:7285-7295 (2008)

 

Kimura J, Nguyen ST, Liu H, Taira N, Miki Y, and Yoshida K. A functional genome-wide RNAi screen identifies TAF1 as a regulator for apoptosis in response to genotoxic stress. Nucleic Acids Res. 36:5250-5259 (2008)

 

Shinagawa H, Miki Y, and Yoshida K. BRCA1-mediated ubiquitination inhibits topoisomerase IIalpha activity in response to oxidative stress. Antioxid. Redox. Signal. 10:939-950 (2008)

 

Tomiyoshi G, Takenaka K, Yoshida K, Miki Y. A novel BRCA2-interacting protein BJ-HCC-20A is involved in promotion of cell growth and in DNA repair in response to DNA damage. Cancer Sci. 99:747-754 (2008)

 

Yoshida K. Nuclear trafficking of pro-apoptotic kinases in response to DNA damage. Trends. Mol. Med. 14:305-313 (2008)

 

Yoshida K. Role for DYRK family kinases on regulation of apoptosis. Biochem. Pharmacol. 76:1389-1394 (2008)

 

吉田清嗣　『DNA傷害におけるシグナル伝達機構とアポトーシス誘導制御』「生化学」80: 619-631 (2008)

 

<2007>

 

Liu H, Lu Z-G, Miki Y, and Yoshida K. Protein kinase C delta induces transcription of the TP53 tumor suppressor by controlling death-promoting factor Btf in the apoptotic response to DNA damage. Mol. Cell. Biol. 27:8480-8491 (2007)

 

Yamaguchi T, Miki Y, and Yoshida K. The USP11 deubiquitinating enzyme controls an IKKalpha-p53 signaling pathway in response to TNFalpha. J. Biol. Chem. 282:33943-33948 (2007)

 

Yamaguchi T, Miki Y, and Yoshida K. Protein kinase C delta activates IkappaB-kinase a to induce the p53 tumor suppressor in response to oxidative stress. Cell. Signal. 19:2088-2097 (2007)

 

Taira N, Nihira K, Yamaguchi T, Miki Y, and Yoshida K. DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. Mol. Cell 25:725-738 (2007)

 

　プレスリリースはこちら

　Highlighted in ‘Previews’ of Mol. Cell 25:794-796 (2007)

　新聞報道（読売新聞、毎日新聞、時事通信、日刊工業新聞、化学工業日報、科学新聞）

 

Yoshida K. PKCdelta signaling: mechanisms of DNA damage response and apoptosis. Cell. Signal. 19:892-901 (2007)

 

Yoshida K. Regulation for nuclear targeting of the Abl tyrosine kinase in response to DNA damage. In: d’Adda di Fagagna F, Chiocca S, McBlane F, and Cavallaro U (eds), Advances in Molecular Oncology. in ‘Advances in Experimental Medicine and Biology’ Vol. 604, Springer Science & Business Media. pp.155-165 (2007)

 

吉田清嗣　『DNA損傷におけるp53のアポトーシス誘導能を制御するSer46キナーゼDYRK2』「細胞工学」  26:672-673 (2007)

 

吉田清嗣　『DNA傷害による細胞死誘導の仕組み−p53のリン酸化制御とアポトーシス−』「Medical Technology」23:896-897 (2007)